![]() The severity of metabolic alterations is the main risk factor for progressive NAFLD, but the qualitative components of diet, physical activity and genetic factors also play an important role. There is a significant interindividual variability in the susceptibility to liver disease. Although liver‐related mortality is common, the most common cause of death in patients with NAFLD is related to cardiovascular diseases, followed by extra‐hepatic cancers. In fact, recent estimates suggest that 25% of the world have NAFLD, which is now one of the leading causes of cirrhosis and indications for liver transplantation. Although only a small proportion of NAFLD patients will progress to end‐stage liver disease and death, the clinical burden of NAFLD is substantial due the sheer number of individuals affected worldwide. Non‐alcoholic fatty liver disease (NAFLD) is the fastest growing cause of chronic liver disease worldwide.
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